Reuters

TOKYO (Reuters) - Asian shares were under pressure on Wednesday, with a rise in U.S. bond yields above the 3 percent threshold and warnings from bellwether U.S. companies of higher costs driving fears that corporate earnings growth may peak soon.

LONDON/NEW YORK (Reuters) - London-listed drugmaker Shire Plc said it was willing to recommend a deal with Takeda Pharmaceutical Co to its shareholders, after the Japanese company sweetened its acquisition offer to 46 billion pounds ($64 billion).

TIJUANA, Mexico (Reuters) - Dozens of Central American migrants from about 600 traveling in a "caravan" through Mexico arrived at the border city of Tijuana late on Tuesday despite warnings it would be futile to try to cross to claim asylum in the United States.

(Reuters) - Rapper Meek Mill, who had been incarcerated for five months on a probation violation, was released from a Pennsylvania jail on Tuesday, his attorney said, after the state's top court granted him bail, capping a star-laden campaign to have him freed.

LAGOS (Reuters) - Semi-nomadic herdsmen armed with guns killed 16 people on Tuesday in an attack on a church congregation in a central state of Nigeria plagued by communal violence, police said.

WASHINGTON (Reuters) - U.S. President Donald Trump's physician Ronny Jackson will push ahead as the nominee to lead the Veterans Affairs department after allegations about his conduct stalled his Senate hearing for the job, a White House official said on Tuesday.

WASHINGTON (Reuters) - U.S. President Donald Trump said on Tuesday a new North American Free Trade Agreement could be agreed on quickly, as Canada hailed progress on forging new rules for the auto industry, the pivotal issue in talks to revamp the 24-year-old accord.

WASHINGTON (Reuters) - U.S. President Donald Trump's physician Ronny Jackson will not withdraw as the nominee to head the Veterans Affairs department and will fight allegations about his conduct that surfaced ahead of a Senate confirmation hearing, a White House official said on Tuesday.

NEW YORK (Reuters) - Wall Street dropped sharply on Tuesday as warnings by bellwether companies of higher costs reverberated as the benchmark U.S. 10-year Treasury yield pierced the 3 percent level for the first time in four years.

WASHINGTON (Reuters) - The U.S. Environmental Protection Agency proposed a rule on Tuesday that would limit the kinds of scientific research it can use in crafting regulations, an apparent concession to big business that has long requested such restrictions.

LONDON/NEW YORK (Reuters) - London-listed drugmaker Shire Plc and Japan's Takeda Pharmaceutical Co Ltd plan to announce a preliminary merger deal as early as Wednesday, after the latter sweetened its $62 billion acquisition offer, three people familiar with the matter said.

NEW YORK (Reuters) - Bitcoin rose to a six-week high on Tuesday on positive headlines that included the possible entry of major financial institutions into the space, lifting sentiment on the overall cryptocurrency market.

TORONTO (Reuters) - The man accused of plowing a rental van into pedestrians on a crowded Toronto sidewalk, killing 10 people, in Canada's deadliest mass killing in decades left a "cryptic message" on social media before his attack, police said on Tuesday.

WASHINGTON (Reuters) - The Environmental Protection Agency announced a new rule on Tuesday that would stop it from relying on scientific research underpinned by confidential data in its making of regulations.

WASHINGTON (Reuters) - President Donald Trump and French President Emmanuel Macron pledged on Tuesday to seek stronger measures to contain Iran, as the U.S. leader considers whether to ditch an international accord meant to prevent Tehran from obtaining a nuclear weapon.

LOS ANGELES (Reuters) - The largest U.S. manager of prescription benefits is telling drugmakers that the current pricing model is broken, and taking aim at Amgen Inc, Eli Lilly and Co and other makers of new migraine medicines to try and fix it.

WASHINGTON (Reuters) - U.S. consumer confidence rebounded in April and new home sales increased more than expected in March, pointing to underlying strength in the economy despite signs that growth slowed in the first quarter.

(Reuters) - Wall Street dropped sharply on Tuesday as concerns over marquee companies warning of higher costs were exacerbated by the benchmark U.S. 10-year Treasury yield piercing the 3-percent level for the first time in four years.

(Reuters) - Coca-Cola Co said on Tuesday it would take a hit in the second quarter from the introduction of a British sugar tax on soft drinks and rising freight costs in the United States, overshadowing modestly better than forecast results for the first three months of 2018.

(Reuters) - A sharp drop in so-called 'FAANG' group of technology stocks pushed the Nasdaq Composite lower on Tuesday, with rising 10-year yields and contrasting earnings reports from industrials also adding to the pressure.